Formulation of an anthelmintic syrup based on the seeds of Carica papaya (Caricaceae)

نویسندگان

چکیده

In traditional medicine, of Carica papaya (Caricacea) seeds are used as a coarse powder, in maceration or an aqueous decoction, for the management helminthiasis. With aim contributing to helminthiasis, this study set out develop syrup with anthelmintic properties based on L. The fluid extract was prepared and subjected phytochemical screening. A physicochemical microbiological stability control. To assess effectiveness syrup, pilot initiated. stools 441 children aged between 5 15 years were examined using Kato-katz technique. secondary metabolites present polyphenols (1.2 g EAT/ml), alkaloids, catechic tannins, flavonoids mucilages. contained 15.15% responded favorably pharmacotechnical tests European Pharmacopoeia 9th edition. Only 43 tested positive helminth eggs. L proved be comparable Albendazole Ascaris lumbricoides (97.46% reduction rate) Trichuris trichiura (100% after two administrations 20 ml 14 days apart. treatment also effective against Necator americanus Tenia sp; but number cases these last parasitoses too low allow any reliable conclusion. Ultimately, solution

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ژورنال

عنوان ژورنال: GSC biological and pharmaceutical sciences

سال: 2023

ISSN: ['2581-3250']

DOI: https://doi.org/10.30574/gscbps.2023.24.3.0368